منابع مشابه
Microbial alkaline phosphatases in bioprocessing
Microorganisms producing alkaline phosphatases are wide spread in nature. Alkaline phosphatase (Orthophosphoric monoester phosphohydrolase, E.C.3.1.3.1) is a hydrolase enzyme functioning at alkaline pH. The metalloenzyme containing the two zinc ions are involved in catalysis whereas the magnesium ion is important in structural stabilization (Simpson et al., 1968; Anderson et al., 1975). The enz...
متن کاملSubcellular localization of marine bacterial alkaline phosphatases.
Bacterial alkaline phosphatases (APases) are important enzymes in organophosphate utilization in the ocean. The subcellular localization of APases has significant ecological implications for marine biota but is largely unknown. The extensive metagenomic sequence databases from the Global Ocean Sampling Expedition provide an opportunity to address this question. A bioinformatics pipeline was dev...
متن کاملEvolution of alkaline phosphatases in primates.
Alkaline phosphatase [orthophosphoric-monoester phosphohydrolase (alkaline optimum), EC 3.1.3.1] in placenta, intestine, liver, kidney, bone, and lung from a variety of primate species has been characterized by quantitative inhibition, thermostability, and immunological studies. Characteristic human placental-type alkaline phosphatase occurs in placentas of great apes (chimpanzee and orangutan)...
متن کاملInhibition of human alkaline phosphatases by vanadate.
Orthovanadate was shown to be a potent competitive inhibitor (Ki less than 1 microM) of purified alkaline phosphatase from human liver, intestine of kidney. Inhibition was reversed and full enzymic activity restored in the presence of 1mM-adrenaline. Phosphate and vanadate competed for the same binding site on the enzyme.
متن کاملThe Effect of Zinc on Alkaline Phosphatases”
Zinc has been shown to be an element essential to the life and growth of rats, but as yet there is no clear indication of what its function may be in metabolism. There are several reports of the occurrence of zinc in pure biological compounds. Scott and Fisher (1) have shown zinc to be necessary for the crystallization of insulin, although other metals were also effective. Keilin and Mann (2) r...
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ژورنال
عنوان ژورنال: Purinergic Signalling
سال: 2006
ISSN: 1573-9538,1573-9546
DOI: 10.1007/s11302-005-5435-6